Our current work involves the study of how molecules function, based on their atomic structure. In order to analyze complex proteins involved in cancer, we make use of overexpression strategies in eukaryotic cell culture systems, particulary Drosophila cells. We have been concentrating on, among others, enzymes involved in glycosylation, particularly glycosyl hydrolases, as potential therapeutic targets. We use a variety of techniques in our lab, but specialize in x-ray crystallography and computer-assisted molecular modelling.

We are located in the Toronto Medical Discovery Tower in the MaRS complex. We are affiliated with the University Health Network and the Department of Medical Biophysics in the University of Toronto.