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David Rose's publications (PubMed)

  • Kawatkar, S, Kuntz DA, Woods RJ, Rose DR and Boons G-J. The Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions. . J. Am. Chem. Soc., 128(25):8310-8319, 2006.

  • Rossi EJ, Sim L, Kuntz DA, Hahn D, Johnston BD, Ghavami A, Szczepina MG, Kumar NS, Sterchi EE, Nichols BL, Pinto BM and Rose DR. Inhibition of Recombinant Human Maltase Glucoamylase by Salacinol and Derivatives. FEBS Journal, 273(12):2673-2683, 2006.

  • Liu H, Sim L, Rose DR, and Pinto BM. A new class of glucosidase inhibitor: analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain extension. J Org Chem, 71:3007-13, 2006.

  • Kuntz DA, Liu H, Bols M, and Rose DR. The role of the active site Zn in the catalytic mechanism of the GH38 Golgi -mannosidase II: implications from noeuromycin inhibition. Biocatalysis and Biotransformation, 24:55-61, 2006.

  • Scotter AJ, Kuntz DA, Saul M, Graham LA, Davies PL, Rose DR. Expression and purification of sea raven type II antifreeze protein from Drosophila melanogaster S2 cells. Protein Expr Purif, 47:374-383, 2006.

  • Kavlekar LN, Kuntz DA, Xin W, Johnston BD, Svensson B, Rose DR and Pinto BM. 5-Thio-D-glycopyranosylamines and their amidinium salts as potential transition state mimics of glycosyl hydrolases: Synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling. Tetrahedron Asymmetry, 16:1035-46, 2005.

  • Wen X, Yuan Y, Kuntz DA, Rose DR, and Pinto BM. A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II. Biochemistry. 44(18):6729-6737, 2005.

  • Kuntz DA, Ghavami A, Johnston BD, Pinto BM and Rose DR. Crystallographic analysis of the interactions of Drosophila melanogaster Golgi a-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues. Tetrahedron Asymmetry, 16:25-32, 2005.

  • Shah N, Kuntz DA and Rose DR. Comparative structural analysis of the binding of the inhibitor kifunensine to Class I and Class II alpha-mannosidases. Biochemistry, 42: 13812-13816. 2003.

  • Numao S, Kuntz DA, Withers SG and Rose DR. Insights into the mechanism of Drosophila melanogaster Golgi a-mannosidase through the structural analysis of covalent reaction intermediates; J Biol Chem, 278: 48074-48083, 2003.

  • Gombos Z, Durussel I, Ikura M, Rose DR, Cox JA and Chakrabartty A. Differential effects of Mg2+ and Ca2+ on the three state folding of Calexcitin B; Biochemistry, 42: 5531-5539, 2003.

  • Boraston AB, Notenboom V, Warren RAJ, Kilburn DG, Rose DR and Davies G. Structure and ligand binding of carbohydrate-binding module CsCBM6-3 reveals similarities with fucose-specific lectins and galactose-binding domains; J Mol Biol, 327: 659-669, 2003.

  • van den Elsen JMH, Martin A, Wong V, Clemenza L, Rose DR and Isenman DE. X-Ray Crystal Structure of the C4d Fragment of Human Complement Component C4, J Mol Biol, 322:1103-1115, 2002.

  • Boraston AB, Nurizzo D, Notenboom V, Ducros V, Rose DR, Kilburn DG and Davies GJ. Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules; J Mol Biol, 319:1143-1156, 2002.

  • Notenboom V, Boraston AB, Williams SJ, Kilburn DG, Rose DR. High-Resolution Crystal Structures of the Lectin-like Xylan Binding Domain from Streptomyces lividans Xylanase 10A with Bound Substrates Reveal a Novel Mode of Xylan Binding. Biochemistry, 41(13):4246-4254, 2002.

  • Wicki J, Rose DR, Withers SG. Trapping covalent intermediates on beta-glycosidases. Methods Enzymol, 354:84-105, 2002.

  • Heike Y, Kasono K, Kunisaki C, Hama S, Saijo N, Tsuruo T, Kuntz DA, Rose DR, Curiel DT. Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv. Int J Cancer, 92:115-22, 2001.
  • Notenboom V, Boraston AB, Chiu P, Freelove AC, Kilburn DG, Rose DR. Recognition of cello-oligosaccharides by a family 17 carbohydrate-binding module: an X-ray crystallographic, thermodynamic and mutagenic study. J Mol Biol 314(4):797-806.3, 2001.

  • van den Elsen JM, Kuntz DA, Rose DR. Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. EMBO J 20(12):3008-17, 2001.

  • Notenboom V, Boraston AB, Kilburn DG, Rose DR. Crystal structures of the family 9 carbohydrate-binding module from Thermotoga maritima xylanase 10A in native and ligand-bound forms. Biochemistry 40(21):6248-56, 2001.

  • Notenboom V, Williams SJ, Hoos R, Withers SG and Rose DR. Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars. Biochemistry, 39:11553-63, 2000.

  • Williams SJ, Notenboom V, Wicki J, Rose DR and Withers SG. A New, Simple Inhibitor of a Retaining Xylanase: Use in Probing the Roles of an Active Site Residue. J Am Chem Soc, 122:4229-4230, 2000.

  • Van den Elsen J, Kuntz DA, Hoedemaeker FJ, and Rose DR. Antibody C219 recognizes an alpha -helical epitope on P-glycoprotein. Proc Natl Acad Sci USA, 96:13679-13684, 1999.

  • Rabouille C, Kuntz DA, Lockyer A, Watson R, Signorelli T, Rose DR, van den Heuvel M and Roberts DB. The Drosophila GMII gene encodes a Golgi alpha-mannosidase II, J Cell Science, 112:3319-3330, 1999.

  • Hsu EC, Sabatinos S, Hoedmaeker FJ, Rose DR and Richardson CD. Use of Site-Specific Mutagenesis and Monoclonal Antibodies to Map Regions of CD46 That Interact with Measles Virus H Protein. Virology, 258:314-326, 1999.