Below are synopses of current projects in the Rose lab. Please
the titles or images to investigate each project further.
Structural studies of
||We are using the Drosophila
homologue of Golgi alpha-mannosidase II to understand the catalytic
mechanism of the mammalian enzyme and design novel anti-metastatic
agents that specifically inhibit this activity. Other
medically-relevant hydrolases under study include lysosomal mannosidase
and intestinal maltase glucoamylase.
Drosophila expression system
||This project involves
Drosophila expression system for routine work in
structure/function studies, evaluating the approach for diverse classes
of molecules, and applying the approach to macromolecules of