Below are synopses of current projects in the Rose lab. Please
click on
the titles or images to investigate each project further.
Structural studies of
glycosyl hydrolases
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We are using the Drosophila homologue of Golgi alpha-mannosidase II to understand the catalytic mechanism of the mammalian enzyme and design novel anti-metastatic agents that specifically inhibit this activity. Other medically-relevant hydrolases under study include lysosomal mannosidase and intestinal maltase glucoamylase. |
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This project involves optimizing the Drosophila expression system for routine work in structure/function studies, evaluating the approach for diverse classes of molecules, and applying the approach to macromolecules of medical/biological interest. |